NOTE: Because of some difficulties with downloading documents from journal sites (people being asked to pay subscription fees) I've downloaded all of the PDF files to this server. To read and print these files you will need the password given in class on January 29. If you don't have that password, E-mail me and I will provide it.
| Tu 1/29: | None |
| Th 1/31: | Review: Orphanides G, Reinberg D. A unified theory of gene expression. Cell. 2002 108:439-451. [Pubmed] [PDF] |
| Tu 2/5: | Review: Hahn S. Structure and mechanism of the RNA polymerase II transcription machinery. Nat Struct Mol Biol. 2004 11:394-403. [Pubmed] [PDF] |
| Th 2/7: | Review: Khorasanizadeh S. The nucleosome: from genomic organization to genomic regulation. Cell. 2004 116:259-272. [Pubmed] [PDF] |
| Tu 2/12: | Review: Berger SL. The complex language of chromatin regulation during transcription. Nature. 2007 447:407-412. [Pubmed] [PDF] |
| Th 2/14: |
Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature. 2001 410:116-120. [Pubmed] [PDF] Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature. 2001 410:120-124. [Pubmed] [PDF] |
| Tu 2/19: | Adkins MW, Williams SK, Linger J, Tyler JK. Chromatin disassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators. Mol Cell Biol. 2007 27:6372-6382. [Pubmed] [PDF] |
| Th 2/21: | Review: Sims RJ, Belotserkovskaya R, Reinberg D. Elongation by RNA polymerase II: the short and long of it. Genes Dev. 2004 18:2437-2468. [Pubmed] [PDF] |
| Tu 2/26: |
Belotserkovskaya R, Oh S, Bondarenko VA, Orphanides G, Studitsky VM, Reinberg D. FACT facilitates transcription-dependent nucleosome alteration. Science. 2003 301:1090-1093. [Pubmed] [PDF] Kaplan CD, Laprade L, Winston F. Transcription elongation factors repress transcription initiation from cryptic sites. Science. 2003 301:1096-1099. [Pubmed] [PDF] |
| Th 2/28: | None [We are meeting in the library to learn about resources and will have a review session afterwards in BS004--see the Class Schedule page for details] |
| Tu 3/4: | Midterm I (up to 2/26) |
| Th 3/6: | Review: Dever TE. Gene-specific regulation by general translation factors. Cell. 2002 108:545-556. [Pubmed] [PDF] |
| Tu 3/11: | Review: Dever TE. Gene-specific regulation by general translation factors. Cell. 2002 108:545-556. [Pubmed] [PDF] |
| Th 3/13: | Review: Jackson RJ. Alternative mechanisms of initiating translation of mammalian mRNAs. Biochem Soc Trans. 2005 33:1231-1241. [Pubmed] [PDF] |
| Tu 3/18: | Spring Break |
| Th 3/20: | Spring Break |
| Tu 3/25: |
Wilson JE, Pestova TV, Hellen CU, Sarnow P. Initiation of protein synthesis from the A site of the ribosome. Cell. 2000 102:511-520. [Pubmed] [PDF] |
| Th 3/27: | Review: Gebauer F, Hentze MW. Molecular mechanisms of translational control. Nat Rev Mol Cell Biol. 2004 5:827-835. [Pubmed] [PDF] |
| Tu 4/1: |
Nelson MR, Leidal AV, Smibert CA. Drosophila Cup is an eIF4E binding protein that functions in Smaug mediated translational repression. EMBO J. 2004 23:150–159. [Pubmed] [PDF] |
| Th 4/3: | None |
| Tu 4/8: | None |
| Th 4/10: | Midterm II (up to 4/1) |
| Tu 4/15: | Review: Isken O, Maquat LE. Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. 2007 Genes Dev. 21:1833-1856. [PubMed] [PDF] |
| Th 4/17: |
Frischmeyer PA, van Hoof A, O'Donnell K, Guerrerio AL, Parker R, Dietz HC. An mRNA surveillance mechanism that eliminates transcripts lacking termination codons. Science. 2002 295:2258-2261. [Pubmed] [PDF] Doma MK, Parker R. Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation. 2006 Nature 440: 561–564. [Pubmed] [PDF] |
| Tu 4/22: |
Review: Grosshans H, Filipowicz W. Molecular biology: the expanding world of small RNAs. Nature. 2008 451:414-416. [Pubmed] [PDF] Review: Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science. 2005 309:1519-1524. [Pubmed] [PDF] |
| Th 4/24: | Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998 391:806-811. [Pubmed] [PDF] |
| Tu 4/29: | None |
| Th 5/1: | Review: Kim VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol. 2005 6:376-385. [Pubmed] [PDF] |
| Tu 5/6: |
Bagga S, Bracht J, Hunter S, Massirer K, Holtz J, Eachus R, Pasquinelli AE. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell. 2005 122:553-563. [Pubmed] [PDF] Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol. 2005 7:719-723. [Pubmed] [PDF] |
| Th 5/8: |
Kiriakidou M, Tan GS, Lamprinaki S, De Planell-Saguer M, Nelson PT, Mourelatos Z. An mRNA m7G cap binding-like motif within human Ago2 represses translation. Cell. 2007 129:1141-1151. [Pubmed] [PDF] Mathonnet G, Fabian MR, Svitkin YV, Parsyan A, Huck L, Murata T, Biffo S, Merrick WC, Darzynkiewicz E, Pillai RS, Filipowicz W, Duchaine TF, Sonenberg N. MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science. 2007 317:1764-1767. [Pubmed] [PDF] |
| Tu 5/13: | None |
